解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1394
更新日期:2015-10-01 00:00:00
abstract::Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1117
更新日期:2015-10-01 00:00:00
abstract::The large-Maf transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) has been found to be crucial for insulin transcription and synthesis and for pancreatic β-cell function and maturation. However, insights about the effects of small Maf factors on β-cells are limited. Our goal was to elu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1906
更新日期:2015-10-01 00:00:00
abstract::We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1018
更新日期:2015-10-01 00:00:00
abstract::At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1032
更新日期:2015-08-01 00:00:00
abstract::Dopaminergic (DA) neurons located in the preoptico-hypothalamic region of the brain exert a major neuroendocrine control on reproduction, growth, and homeostasis by regulating the secretion of anterior pituitary (or adenohypophysis) hormones. Here, using a retrograde tract tracing experiment, we identified the neurons...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1091
更新日期:2015-08-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) comprise one of the largest subgroups in the TGF-β ligand superfamily. We have identified a functional BMP system equipped with the ligand (BMP4), receptors (BMP type II receptor, BMP type IA receptor, also called ALK3) and the signaling proteins, namely the mothers against decapenta...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1942
更新日期:2015-07-01 00:00:00
abstract::Recent studies have revealed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Nevertheless, the effect of CNP on bone turnover has not yet been well studied. To elucidate this issue, we investigated the bone phenotype of a mouse model with elevated plasma CNP concentrations (SA...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1801
更新日期:2015-07-01 00:00:00
abstract::The technologies for pancreatic β-cell-specific gene overexpression or knockout are fundamental for investigations of functional genes in vivo. Here we generated the Ins1-Cre-Dsred and Ins1-rtTA mouse models, which expressed the Cre recombinase or reverse tetracycline regulatable transactivator (rtTA) without hGH mini...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1104
更新日期:2015-07-01 00:00:00
abstract::Thyroid hormones (TH) are actively taken up into target cells via TH-transmembrane transporters (THTT). Their activity and expression patterns define a layer of endocrine regulation that is poorly understood. Therefore, THTT are potential targets for interfering agents (endocrine disruptors) as well as for pharmacolog...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1016
更新日期:2015-07-01 00:00:00
abstract::Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac rem...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1162
更新日期:2015-07-01 00:00:00
abstract::Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons. However, the relative contributions of the two functionally distinct kisspeptin neuron subpopulations to this critical regulation are not fully understood. Here we analyzed the specific projection pa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1131
更新日期:2015-07-01 00:00:00
abstract::GnRH is expressed in first-trimester human placenta and increases cell invasion in extravillous cytotrophoblasts (EVTs). Invasive phenotypes have been reported to be regulated by transcription factor activator protein 1 (AP-1) and mesenchymal cadherin-11. The aim of our study was to investigate the roles of AP-1 compo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1871
更新日期:2015-06-01 00:00:00
abstract::The role of anti-Müllerian hormone (AMH) during gonad development has been studied extensively in many species of mammal, bird, reptile, and fish but remains unresolved in amphibians. In male mammalian embryos, Sox9 activates AMH expression, which initiates regression of the Müllerian ducts. However, Sox9 (Sry-related...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2053
更新日期:2015-05-01 00:00:00
abstract::Testosterone treatment induces erythrocytosis that could potentially affect blood viscosity and cardiovascular risk. We thus investigated the effects of testosterone administration on blood viscosity and erythrocyte deformability using mouse models. Blood viscosity, erythrocyte deformability, and hematocrits were meas...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1784
更新日期:2015-05-01 00:00:00
abstract::In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1941
更新日期:2015-05-01 00:00:00
abstract::Kisspeptin, encoded by the Kiss1 gene, binds to a specific G protein-coupled receptor (kisspeptin1 receptor) to regulate the central reproductive axis. Kisspeptin has also been reported to be expressed in peripheral tissues, including the testes. However, factors regulating testicular kisspeptin and its role in reprod...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1606
更新日期:2015-04-01 00:00:00
abstract::Glucocorticoid hormones are involved in functional differentiation of GH-producing somatotrophs. Glucocorticoid treatment prematurely induces GH expression in mammals and birds in a process requiring protein synthesis and Rat sarcoma (Ras) signaling. The objective of this study was to investigate mechanisms through wh...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1686
更新日期:2015-03-01 00:00:00
abstract::The aim of this study was to determine whether bisphenol A (BPA) has adverse effects on cardiovascular functions in CD-1 mice and define sex-specific modes of BPA action in the heart. Dams and analyzed progeny were maintained on a defined diet containing BPA (0.03, 0.3, 3, 30, or 300 ppm) that resulted in BPA exposure...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1847
更新日期:2015-03-01 00:00:00
abstract::Translocator protein (TSPO) is a mitochondrial outer membrane protein of unknown function with high physiological expression in steroidogenic cells. Using TSPO gene-deleted mice, we recently demonstrated that TSPO function is not essential for steroidogenesis. The first link between TSPO and steroidogenesis was establ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1707
更新日期:2015-03-01 00:00:00
abstract::In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1741
更新日期:2015-02-01 00:00:00
abstract::The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T4. We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(fl/fl) mice. There wa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1698
更新日期:2015-02-01 00:00:00
abstract::GnRH release in the median eminence (ME) is the central output for control of reproduction. GnRH processes in the preoptic area (POA) also release GnRH. We examined region-specific regulation of GnRH secretion using fast-scan cyclic voltammetry to detect GnRH release in brain slices from adult male mice. Blocking endo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1458
更新日期:2015-01-01 00:00:00
abstract::Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1436
更新日期:2015-01-01 00:00:00
abstract::Neuropeptide Y (NPY) is highly expressed in the hypothalamus, where it regulates feeding and energy homeostasis. Interestingly, NPY and its receptors are also expressed in peripheral tissues with roles in metabolism, including pancreatic islets. In islets, NPY is known to suppress insulin secretion acutely. In additio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1537
更新日期:2014-12-01 00:00:00
abstract::Transcriptional regulation of metabolic genes in the liver is the key to maintaining systemic energy homeostasis during starvation. The membrane-bound transcription factor cAMP-responsive element-binding protein 3-like 3 (CREB3L3) has been reported to be activated during fasting and to regulate triglyceride metabolism...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1113
更新日期:2014-12-01 00:00:00
abstract::Sex differences in vocal communication are prevalent in both the animals and humans. The mechanism(s) mediating gender differences in human language are unknown, although, sex hormones, principally androgens, play a central role in the development of vocalizations in a wide variety of animal species. The discovery of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1486
更新日期:2014-12-01 00:00:00
abstract::LPXRFamide (LPXRFa) peptides have been characterized for their ability to inhibit gonadotropin (GTH) release in birds and stimulate growth hormone (GH) release in frogs. However, their involvement in regulating the reproductive hypothalamo-pituitary-gonadal axis in mammals and fish is inconclusive. To study the role o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2047
更新日期:2014-11-01 00:00:00
abstract::High plasma levels of estradiol (E2) are associated with use of a place memory system over a response memory system. We examined whether infusing estradiol into the medial prefrontal cortex (mPFC) or anterior cingulate cortex (AC) could affect memory system bias in female rats. We also examined the ultrastructural dis...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1463
更新日期:2014-11-01 00:00:00
abstract::Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2014-1337
更新日期:2014-11-01 00:00:00
abstract::Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1139
更新日期:2014-11-01 00:00:00
abstract::Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of these peptides and their regulated expression by ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1200
更新日期:2014-10-01 00:00:00
abstract::Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1387
更新日期:2014-10-01 00:00:00
abstract::Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2028
更新日期:2014-10-01 00:00:00
abstract::The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient. Dual-labeling for LEP receptors (LEPRs) and gonadotropins or GH revealed a 2-fold increase in LEPR during proestrus, some of which was seen in LH gonadotropes....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1132
更新日期:2014-10-01 00:00:00
abstract::Vitamin D deficiency is associated with a range of muscle disorders, including myalgia, muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) gene are associated with variations in muscle strength, and in mice, genetic ablation of VDR results in muscle fiber atrophy and motor deficits. H...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1016
更新日期:2014-09-01 00:00:00
abstract::Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)]c) and insulin secretion in mouse islets. Alone PKA activator ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1247
更新日期:2014-09-01 00:00:00
abstract::The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1002
更新日期:2014-09-01 00:00:00
abstract::Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1820
更新日期:2014-09-01 00:00:00
abstract::Thyroid hormone (T3) is required for postnatal skeletal growth. It exerts its effect by binding to nuclear receptors, TRs including TRα1 and TRβ1, which are present in most cell types. These cell types include chondrocytes and osteoblasts, the interactions of which are known to regulate endochondral bone formation. In...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1109
更新日期:2014-08-01 00:00:00